Oprah reveals her favorite guest

Oprah reveals her favorite guest

Oprah reveals her favorite guest. On Friday's edition of "The Oprah Winfrey Show," the talk-show icon finally sits down and revealed who she feels -- out of 25 years on television -- is her favorite guest ever on the show. This was inevitably a difficult decision to make, but Oprah's rationale seemed to be choosing someone for what they have accomplished and also how they inspired others -- and also has little to do with whether or not they are famous.